ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

This drug is not an effective treatment for a viral infection e. No data are available regarding use in pediatric patients with renal impairment.

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For the treatment of complicated urinary tract infection UTI pyelonephritisincluding cases with concurrent bacteremia. Your Name Your name is required. Patients at ertapeenm risk for seizures may include: Accumulation does not occur following multiple IM doses in healthy adults.

For less than 1 g dose: If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental dosing is required.

Prior to initiating ertapenem therapy, the patient should be carefully questioned about previous penicillin hypersensitivity, cephalosporin hypersensitivity, allergic reactions to other beta-lactams e. Minor Probenecid inhibits the renal excretion packagee ertapenem by competing with them for active tubular secretion.

Therefore, these antibiotics should be taken at least 2 hours before and inset less than 6 hours after the administration of sodium picosulfate; magnesium oxide; anhydrous citric acid solution.

Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria. No dosage adjustment needed. No intraoperative redosing and duration of prophylaxis less than 24 hours are suggested by clinical practice guidelines.

Use within ertapenek hour after preparation.

Ertapenem is suggested as an option for moderate to severe diabetic wound infections. FDA-approved dosage in renal failure for adults: If an allergic reaction occurs, discontinue the drug and initiate appropriate emergency treatment with epinephrine, oxygen, IV steroids, intubation or other therapy as indicated. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions. Like meropenem, but unlike imipenem, it has a 1-beta-methyl substituent and does not require protection with an inhibitor of human renal dihydropeptidase I.

There is a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase. If diarrhea develops during therapy, the drug should be discontinued. If ertapenem is given within 6 hours of hemodialysis, a supplementary dose of mg is recommended following the hemodialysis session. Antibiotic therapy should be administered until further debridement is not necessary, the patient has improved clinically, and fever has been absent for 48 to 72 hours.

During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances.

In some instances, this effect is used therapeutically to unsert availability of the antimicrobial agent. In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted.

If the drugs are coadministered and serum valproic acid concentrations cannot be maintained or if seizures occur, alternative antibacterial or anticonvulsant therapy should be considered. PBPs vary among different bacterial species. Ertapenem is excreted in human breast milk. Guidelines recommend ertapenem for 4 to 7 days for community-acquired infections. By day 5 after discontinuation, the concentration in breast milk was undetectable. Practitioners should be aware that antibiotic-associated colitis has been observed ertapdnem occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken.

Anticonvulsant therapy should be initiated if indicated and the dose of ertapenem should be re-evaluated based on the patient’s renal function. Consider transitioning to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated.

Ertapenem Sodium Injection – Par Sterile Products – Products

Safety and wrtapenem have not been established. Ertapenem is administered via intravenous IV or intramuscular IM routes. Monitor patients for signs and symptoms of bleeding. Dilute the appropriate volume of the reconstituted solution based on body weight in 0. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall.

Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening.

Further dilution is necessary for IV infusion. Patients should be told to complete the full course of treatment, even if they feel better earlier.

Surgical intervention is the primary therapeutic intervention. Inseert Drug Information Drug Summary. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis.