Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations – Evaluation. DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE. Health Concerns of the Ingredient: Overall Hazard. Cancer. Developmental & reproductive toxicity. Opinion on diethylamino hydroxybenzoyl hexyl benzoate. 2. About the Scientific Committees. Three independent non-food Scientific.
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Identifying those ingredients that are safe and those that pose a realistic threat to marine ecosystems. Encouraging the manufacture of reef-friendly sunscreens. Damage and deformation of coral larvae planulae. Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at nm [ 1 ].
Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular:. Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe inand is also marketed in the U. Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro [ 4 ]. Based on viethylamino findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum [ 4 ].
Diethylamino hydroxybenzoyl hexyl benzoate. Most experiments have also been of relatively short duration 12 or 24 hours.
Further research is needed to better understand which ingredients are safe and which pose a realistic threat to marine ecosystems, in particular: Diethylamino hydroxybenzoyl hexyl benzoate 0. In general, concentrations of UV filters used in experimental work have been higher than likely to be encountered in the reef environment. This effect is more pronounced at higher water temperatures.
Research to date has also concentrated mainly on the effects of sunscreens and individual chemicals at subcellular, cellular and individual organism level, with very few studies of wider impacts. Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state [ 1 ].
Trade Name:Diethylamino Hydroxybenzoyl Hexyl Benzoate|CAS Noc Chemical
In rat and porcine skin, the percutaneous absorption was 0. The following measures are recommended: Damage to coral DNA and to their reproductive success.
No case of overdose has been reported. Considering the many stresses already faced by reefs and current concerns about the toxicity of certain components of sunscreens to corals, a proactive and precautionary approach to dealing with this issue may be required.
The chemical UV filter oxybenzone has been studied most intensively and the following effects have been described:. On the reef, while UV filters may be at lower concentrations, they can accumulate in organisms and sediment and thus become persistent, with largely unknown consequences. In vitrotopical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation [ 3 ].
Investigating the effects of sunscreen pollutants at reef community and ecosystem level. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability [ 1 ].
Investigating UV filter toxicity in relation to predicted warming and ocean acidification conditions. Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin [ 2 ].
Diethylamino hydroxybenzoyl hexyl benzoate – Wikiwand
They also contain inactive ingredients such as anti-microbial preservatives, moisturisers and anti-oxidants. Researching the extent and significance of bio-concentration and bio-accumulation of organic UV filters as well as the consequences of long-term, chronic exposure to sunscreen pollutants.
The following benzoatr are recommended:. They are generally found at barely detectable levels of a few parts per trillion but much higher concentrations of over 1 part per million ppm have been reported in a few locations e.
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Where sunscreen components have been detected, concentrations are very variable. Drug created on December 03, Reducing the amount of harmful sunscreen components that reach the reef environment is a high priority and hexul require the involvement of governments, reef managers, divers, snorkelers and swimmers, and the tourism and pharmaceutical industries.
Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions [ 4 ]. Impacts of sunscreens on coral reefs.
Studying the effects of pharmaceutical and personal care products PPCP mixtures to provide a more realistic picture of ecological risks posed by the use of these products. A small number of studies have shown that sunscreen and certain individual components of sunscreen can have negative effects on corals and other marine organisms under certain circumstances.
Many of these components have also been found in marine biota including fish, molluscs and corals as well as in sediments. The chemical UV filter oxybenzone has been studied most intensively and the following effects hyxroxybenzoyl been described: To date, experiments have largely been undertaken ex-situ and there are concerns that they may not properly reflect conditions on the reef, where pollutants could be rapidly dispersed and diluted.
Induction of the lytic viral cycle in symbiotic zooxanthellae with latent infections. Bleaching of coral fragments and coral cells from various species of hard coral.