Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.
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Seifert G, Sobin LH. Thus, the aim of this study was to analyze a series of intraoral MEC for expression of the c-erbB-2 oncoprotein and its possible association with the clinicopathologic features of the sample.
Although MEC has been described as salivalse radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test.
Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. In our series the results were similar with 21 The use of skim milk as an economical and effective substitute for commercial biotin solutions.
Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable. Published works usually lose relevant survival information through time. The high percentage of previously observed positive cases 21 cases, Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 cases. Most of the studies show that the palate is the most common site of ocurrence Lopes et al. The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography.
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Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Few papers evaluating only one type of oral salivary gland tumors are available. Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: Mucoepidermoid carcinoma of the salivary glands. Pattern of parotid gland tumors on Crete, Greece: However, its prognostic value should be validated with clinical studies and survival analyses.
For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed.
Discrepancies were solved by consensus. Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours. In the present study, was set out to examine MEC behavior and patient outcomes to provide additional information on potential factors that could significantly affect the prognosis of these tumors.
Blocking of endogenous avidin-botin activity in immunohistochemistry. High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al.
There were 16 cases of MEC diagnosed over an year period at our institution, which is similar to results reported by Triantafillidou and others 14 who found 16 cases over a year interval. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma.
The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion. Different conclusions may be attributed to the varying techniques used, criteria applied to determine positive c-erbB-2 expression, the diversity of lesions and the limited number evaluated in some studies.
The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates. Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs. R; Dempsey, R J. MECs were staged according to the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas.
The follow-up period in this study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both University of Sao Paulo, Brazil. Salivary glands ; ucoepidermoid carcinoma ; Prognostic factors. There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al.
Mucoepidermoid carcinoma of the head and neck: Although the significance of this cytoplasmic staining remains unknown, Cheng et al. Clinicopathologic and immunohistochemical study carcinnoma intraoral mucoepidermoid carcinoma.
Evaluation of the immunohistochemical staining. Mucoepidermoid Carcinoma of Salivary Glands: Ann Otol Rhinol Laryngol. Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC. Jpn J Clin Oncol. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival.