Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.
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Official BYETTA® (exenatide) injection Healthcare Professional Website
Both hyperglycemia and hypoglycemia have been described in patients treated with acetazolamide. Based on animal data, advise pregnant women of the potential risk to a paxkage.
Patients receiving incretin mimetics should be closely monitored for changes in glycemic control. Blood glucose should be closely monitored and bydtta agents adjusted accordingly in this situation.
Exenatide should not be administered after a meal. The mean apparent clearance of exenatide in humans is 9. Your Name Your name is required.
Exenatide acutely improves glycemic control by reducing fasting and postprandial glucose concentrations in patients byetfa type 2 diabetes. Tell your healthcare provider if you have or had kidney problems or a kidney transplant. If pancreatitis is suspected, BYETTA should be discontinued promptly and should not be restarted if pancreatitis is confirmed.
Tobacco smoking is known to aggravate insulin resistance. Approved Uses BYETTA is an injectable prescription medicine that may improve blood sugar glucose control in adults with type 2 diabetes, when used with diet and exercise.
Patients should be advised to eat within 20 minutes of mecasermin administration. Temporary use of insulin in place of oral antidiabetic agents may be necessary during periods of physiologic stress e. When using exenatide byettaa basal insulin, administer as separate injections.
The main risk factors for impaired glucose tolerance due to corticosteroids are the dose of steroid and duration of treatment. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Moderate Pentamidine can be harmful to pancreatic cells.
Inject subcutaneously into the thigh, abdomen, or upper arm. Let the autoinjector come to room temperature for approximately 15 minutes before administration. Postmarketing reports of increased international normalized ratio INR sometimes associated with bleeding with concomitant use of warfarin. Furthermore, because exenatide is a peptide, it will most likely be digested in the stomach of a nursing infant.
Lower glucagon concentrations lead to decreased hepatic glucose output and decreased insulin demand. Patients who are taking antidiabetic agents should monitor for worsening glycemic control when a phenothiazine is instituted.
If a patient develops hypoglycemia during treatment, adjust anti-diabetic drug regimen accordingly. It is acceptable for the injections to be in the same body region byettw the injections should NOT be adjacent to each other. Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Patients receiving incretin mimetics should be closely monitored for signs indicating loss of diabetic control when therapy with a hydantoin is instituted.
Add BYETTA to insulin glargine as a complementary action to help improve glycemic control
Safety and effectiveness of exenatide have not been established in children or adolescents under 18 years of age. After injection, an orange rod will appear in the window. Exenatide has also been shown to reduce food intake in both byettx and humans, which may help to control weight. You pcakage report side effects related to AstraZeneca products by clicking here. Because hypoglycemic events may be difficult to recognize in some elderly patients, antidiabetic agent regimens should be carefully managed to obviate an increased risk of severe hypoglycemia.
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Dosage adjustments of anti-diabetic medications should be considered. No placebo-treated patients withdrew due to nausea or vomiting. Patients who develop severe abdominal pain while on exenatide should be evaluated as this could be a warning sign for a serious condition. While still holding the autoinjector upright, unscrew the orange cap. In five to week trials, no major hypoglycemia was reported for extended-release exenatide suspension or comparator-treated patients. The manufacturer of ihsert provides an insulin glargine dose titration algorithm to aide clinicians when using exenatide with insulin glargine; consult product labels.
Patients receiving these drugs concomitantly should be insfrt for changes in glycemic control.
Monitor blood glucose for needed dosage adjustments with exenatide in diabetic patients whenever a change in either nicotine intake or packag smoking status occurs. Moderate Hypoglycemia, including symptomatic episodes, has been noted in post-marketing reports with linezolid in patients with diabetes mellitus receiving therapy with antidiabetic agents, such as insulin and oral hypoglycemic agents.
Blood glucose monitoring is warranted in patients with type 2 diabetes prior to starting and during lorcaserin treatment. Acetaminophen; Butalbital; Caffeine; Codeine: After 30 days, throw away the pen, even if some medicine remains in it. Limited data with exenatide in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage.
Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. If exenatide is discontinued and bydtta glucose is not controlled on diet and exercise alone, insulin therapy should be byyetta.