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Date: August 29, 2019 Author: admin Comments: 0
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AVONEX PACKAGE INSERT PDF

1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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Gently turn the needle clockwise until firmly attached. Hold syringe upright so that the rubber cap faces up.

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Interferon beta belongs to the class of interferons, which are species-specific proteins produced in response to viruses as well as a variety of other natural and synthetic stimuli. Symptoms of inserh allergic reaction may include shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, rash, itching or hives on the skin. Muscle stiffness or spasms. Discard if the reconstituted product contains particulate matter or is discolored.

Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from

The above list includes very serious side effects. Interferon beta has antiviral activity against herpes virus, human papillomavirus, hepatitis B, hepatitis C, and human immunodeficiency syndrome virus. If a patient does become pregnant while receiving interferon therapy, she should be made aware of the risk. Discharge from the injection site or pain, redness or swelling that does not go away. Withdraw 1 packag of reconstituted solution into a syringe.

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Interferon beta binds to the type 1 interferon receptor with greater affinity than interferon alpha.

Do not be alarmed by the following lists of side effects. Patients pacckage bone marrow suppression may require more intensive monitoring of hematologic parameters, including complete blood counts with differential and platelets.

After 2 hours, check the injection site for redness, swelling, or tenderness. Inject subcutaneously using a dart-like motion into the packaage surface of the upper arm, abdomen, thigh, or buttock.

The biologic responses of interferon beta therapy may be evaluated via the following markers: You may avonrx urgent medical attention. Ordinarily, multiple sclerosis MS patients receiving chronic immunomodulatory therapy should not be treated with natalizumab; however, in some multiple sclerosis clinical trials, patients were allowed to continue interferon beta therapy.

Biogen Australia Pty Ltd.

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Interferon beta is a Type I interferon. Major Consider the potential risk of interferon beta products used in combination with known hepatotoxic drugs or other products e. To prevent or slow the development of clinically definite MS in patients who have experienced a first clinical episode and have MRI features consistent with MS. However, a small number of nursing mothers receiving interferon beta-1a reported no adverse effects in their partially breast-fed infants, and the amount of interferon beta-1a excreted into breast milk appeared to be insignificant.

Use appropriate aseptic technique for preparation of solution.

Although interferon beta-1a is not directly cardiotoxic, serious cardiac adverse events have been reported in patients without a prior history of cardiac disease see Adverse Reactions. You will hear a click if the injection is given the right way.

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The potential of additive effects from multiple drugs or other hepatotoxic agents has not been determined; however, caution is recommended if interferon beta-1a is given concurrently with any hepatotoxic agents. Do not inject into an area of the body where skin is irritated, reddened, bruised, packafe, or scarred in any way.

Major An increased risk and severity of peripheral neuropathy has been reported with telbivudine alone or in combination with pegylated interferon alfa-2a and other interferons. After counting to 10, pull the Pen straight out of the skin. Lamivudine; Tenofovir Disoproxil Fumarate: Take care not to inject intradermally. Liver or kidney problems.

Do this even if there are no signs of discomfort or poisoning. Moderate Monitor for signs and symptoms of hepatic injury during coadministration of riluzole and interferon beta.

Swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing. Additionally, stavudine has been associated with fatal and nonfatal lactic acidosis and hepatomegaly with or without steatosis and should be used cautiously in patients with hepatic disease. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Closely monitor patients for treatment-associated toxicities, especially hematologic effects and hepatic decompensation, and manage as recommended for the individual therapies.

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