Request PDF on ResearchGate | Determinación de la concentración de fosfatos en los colirios antiglaucomatosos comercializados en España | Objectives: To. Quitosana para liberação de fármacos antiglaucomatosos / Juçara. Ribeiro Franca. .. Figura 10 – Inserts oftálmicos para liberação prolongada de fármacos: (a). Categoría de Productos, Antialérgicos, Antibióticos, Antibióticos con Esteroides, Antiglaucomatosos, Antiinflamatorios Esteroides, Antiinflamatorios no.
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RESULTS For the analysis of the results, the products were selected and randomly numbered for the definition of the sequence of data collection. A comparison of active ingredients and preservatives between brand name and generic topical glaucoma medications using liquid chromatography-tandem mass spectrometry.
Desai C, Rajadhyaksha V. Cantor 20 considers that when switching to a generic medicine, neither the patient not the physician can be sure that the new medicine will be well tolerated or effective. In face of the European Medicines Agency, why does the FDA require all active and inactive components of a generic ophthalmic medicine to be exactly the same as in the reference product?
The Maximum Treatment Duration ranged from In this case, the clinical trial must include basal intraocular pressure measurements as well as at week 1, 6 and 12, at least at peak and trough times for the active ingredient. Besides that, in relation to the vial tilt, we found out that there is significant variation in the droplet volume, and there is a concern by manufacturers on this fact, since the directions of 12 out of the 13 brands tested fail to inform the consumer the correct way of instilling the eyedrop.
If it causes discomfort or adverse effects, patients stop using the medicine and often do not report this until the following check up.
In this antiglaucomatosls, we are inclined to suggest that the patient try the generic. The authors consider that substituting an original medicine for a generic medicine could be a trial and error process The results show that there is a trickle pattern between the different vials studied, since the volume of the droplets ranged from Three original vials were tested from 13 brands of tear solution: It was decided not to use the Maximum Consumer Price 7since some of the eyedrops have the status of Free from Taxation According to the average number of droplets contained in each vial and the dosage defined, it was also determined the Maximum Treatment Duration for each eyedrop, as well as the number of vials consumed per year.
Noecker and Simmons 19 state that “There is no doubt we are moving toward a totally generic world, and as our patients adapt to different medicines, we must monitor efficacy and safety vigilantly. To determine the mean drop volume produced by artificial tear solutions in different inclination angles and to determine the mean cost of the treatment. A class effect was considered He concludes that concerns about generic medications will only disappear when comparative studies with original medications are promoted and conducted for efficacy, safety and patient comfort.
The eyedrops were open at the time of test, and the weighing of drops was held by the same researcher, being filed the batch of each vial. The drop volume ranged from Since the effect is produced in mucous membranes or the skin, plasma concentrations are either not high enough to allow drug levels to be determined or, if high enough, they are too small and irregular.
The serum timolol concentrations were 0. Bioequivalence is the comparison between antiglaucomatksos bioavailability of a medicine under study and the bioavailability of a reference drug. The concept of pharmacoeconomics is growing nowadays, and concerns the application of the principles of economics to the study of medications and health practices, aiming at the optimization in the use of financial resources without oftalmicls to quality and treatment outcomes The increased basal active ingredient concentration could be a strategy to compensate the known degradation of drugs over time to levels below their optimal dose, including at room temperature.
By raising the contact time, these agents reduce nasolacrimal absorption and improve systemic safety. The reason is that preservatives such as BAK prevent the pH from increasing beyond 6. Corneal complications were seen after instillation of diclofenac post-operatively after routine ophthalmic procedures. Therefore, the time between follow-up visits should be reduced when patients switch to generics to ensure that the new medicine is working adequately and the patient has no complaints.
The timolol-dorzolamide combination in both brand-name and generic medications is relatively resistant to degradation. Therefore, we realized that the droplet volume of eyedrop is still considerably high, and that this leads to a waste of the product and increased cost to the oftaalmicos and the consumer. Further studies should be anntiglaucomatosos with other classes of eyedrops, and we must worry each time more about the antiglauocmatosos volume of eyedrop, so that an ideal is reached.
La Primer Guia Online de Medicamentos Argentinos
What will be the repercussions on the daily practice of changing antiglaucomatous medications to generics? However, with the sign reversed, the bigger the drop the smaller number of droplets contained in vials will be, increasing the final cost to the consumer.
Although both treatments caused reductions in resting and exercise heart rate, timolol gellan was associated with significantly lower reductions. In the previous edition, the Brazilian Pharmacopeia defined that any measurement tool to antiglaucomatoaos liquid medicines must meet specific volumetric standards: For proper tilt, a protractor antiglaucmoatosos used as a guide in a reference plane, and in relation to the vial base 3,6.
The generic medication had a higher pH and higher particulate matter concentration. Thus, changing the preservative and increasing the pH improved the corneal penetration of brimonidine and increased the drug’s concentration in the aqueous humour.
On average, each medicine comprises five or six patents. Some surfactant preservatives also contribute to keeping lipophilic drugs in solution, such as prostaglandin analogues. Why do generics manufacturers not copy the original medicine exactly? Eye drops contain multiple excipients: No statistically significant differences were observed between both medications at 8 am, nor 2 hours after administration.
Are generics and brand-name medicines the same?* |
When patients ask about replacing a branded product with its generic counterpart, all we can honestly say as doctors is that the new generic medicine has not been studied, analysed or compared to the original medicine, and so we cannot know whether it will act in a similar way — in other words, whether both medicines are equally effective.
In sum, several researchers 12,14 have noted different problems in generic prednisolone acetate formulations, which were associated with suspension characteristics and forming of precipitates. Te average number of droplets contained in each vial was also determined, taking into account the average volume of each drop and the total volume of the vial as advertised by the manufacturer on the product label Which medication component was responsible for corneal complications was not reported.
The official medical eyedropper, according to the American Pharmacopoeia, presents an outter diameter of 3 mm and dispenses 20 drops of distilled water per mL at a temperature of 25oC by positioning the eyedropper perpendicular to the person that will receive the drop 1. Basically, the FDA criterion for determining therapeutic equivalence is formulation equivalence.
For the analysis of the results, the products were selected and randomly numbered for the definition of the sequence of data collection.